LymphedemaV1, Main, Exploration, bibRecord, 001639

Utility of Pelvic MRI and Tumor Markers HE4 and CA125 to Predict Depth of Myometrial Invasion and Cervical Involvement in Endometrial Cancer

Identifieur interne : 001639 ( Main/Exploration ); précédent : 001638; suivant : 001640

Utility of Pelvic MRI and Tumor Markers HE4 and CA125 to Predict Depth of Myometrial Invasion and Cervical Involvement in Endometrial Cancer

Auteurs : Narges Zamani [Iran] ; Mitra Modares Gilani [Iran] ; Fateme Zamani [Iran] ; M. Hossein Zamani [Iran]

Source :

Journal of Family & Reproductive Health [ 1735-8949 ] ; 2015.

RBID : PMC:4818380

Abstract

Objective: The purpose of this pilot study was to determine whether the MRI and biomarkers human epididymis protein 4 (HE₄) and CA₁₂₅ correlate with depth of myometrial invasion, histologic grade, cervical involvement and nodal metastases in patients with endometrioid adenocarcinoma of the uterus.

Materials and methods: This was a prospective, observational study in women with biopsy-proven endometrial adenocarcinoma of the uterus. Preoperative pelvic MRI was performed and concentration of HE₄ and CA₁₂₅were assessed before surgery. All surgical specimens were reviewed by a single expert pathologist. The results were compared with the final histopathology report of surgical staging.

Results: Included were a total of 68 women with endometrioid adenocarcinoma of the uterus, most (76%) with stage I disease. Levels of serum HE₄ greater than 140PM and CA₁₂₅ greater than 35 ku/L were observed in 12 (17%) and 26 (38.2%) of patients respectively whose greater proportion were cases with deep myometrial invasion and high grade tumor. In the evaluation of deep tumoral invasion (> 50%) of the myometrium sensitivity, specificity, and diagnostic accuracy of MRI were 68.9%, 94.8% and 83.8% respectively. For lymph node involvement these values were 50%, 95.1% and 91.1% respectively and for cervical stromal involvement were 64.3%, 98.1% and 91.1% respectively.

Conclusion: Higher stage, deep myometrial invasion, and lymph node or cervical stromal involvement increase diagnostic accuracy of MRI. Higher levels of HE₄ and CA₁₂₅ were observed in patients with deep myometrial invasion and higher grade of tumor.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818380

PubMed: 27047564
PubMed Central: 4818380

Affiliations:

Iran

Le document en format XML

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<author><name sortKey="Zamani, Narges" sort="Zamani, Narges" uniqKey="Zamani N" first="Narges" last="Zamani">Narges Zamani</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Iran</nlm:aff>
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<author><name sortKey="Modares Gilani, Mitra" sort="Modares Gilani, Mitra" uniqKey="Modares Gilani M" first="Mitra" last="Modares Gilani">Mitra Modares Gilani</name>
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<author><name sortKey="Zamani, Fateme" sort="Zamani, Fateme" uniqKey="Zamani F" first="Fateme" last="Zamani">Fateme Zamani</name>
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<author><name sortKey="Zamani, M Hossein" sort="Zamani, M Hossein" uniqKey="Zamani M" first="M. Hossein" last="Zamani">M. Hossein Zamani</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Utility of Pelvic MRI and Tumor Markers HE4 and CA125 to Predict Depth of Myometrial Invasion and Cervical Involvement in Endometrial Cancer</title>
<author><name sortKey="Zamani, Narges" sort="Zamani, Narges" uniqKey="Zamani N" first="Narges" last="Zamani">Narges Zamani</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
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<author><name sortKey="Modares Gilani, Mitra" sort="Modares Gilani, Mitra" uniqKey="Modares Gilani M" first="Mitra" last="Modares Gilani">Mitra Modares Gilani</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
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<author><name sortKey="Zamani, Fateme" sort="Zamani, Fateme" uniqKey="Zamani F" first="Fateme" last="Zamani">Fateme Zamani</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Radiology, Tehran University of Medical Sciences, Tehran, Iran</nlm:aff>
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<wicri:noRegion>Tehran</wicri:noRegion>
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<author><name sortKey="Zamani, M Hossein" sort="Zamani, M Hossein" uniqKey="Zamani M" first="M. Hossein" last="Zamani">M. Hossein Zamani</name>
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<series><title level="j">Journal of Family & Reproductive Health</title>
<idno type="ISSN">1735-8949</idno>
<idno type="eISSN">1735-9392</idno>
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<front><div type="abstract" xml:lang="en"><p><bold>Objective:</bold>
 The purpose of this pilot study was to determine whether the MRI and biomarkers human epididymis protein 4 (HE<sub>4</sub>
) and CA<sub>125</sub>
 correlate with depth of myometrial invasion, histologic grade, cervical involvement and nodal metastases in patients with endometrioid adenocarcinoma of the uterus. </p>
<p><bold>Materials and methods:</bold>
 This was a prospective, observational study in women with biopsy-proven endometrial adenocarcinoma of the uterus. Preoperative pelvic MRI was performed and concentration of HE<sub>4</sub>
 and CA<sub>125 </sub>
were assessed before surgery. All surgical specimens were reviewed by a single expert pathologist. The results were compared with the final histopathology report of surgical staging.</p>
<p><bold>Results:</bold>
 Included were a total of 68 women with endometrioid adenocarcinoma of the uterus, most (76%) with stage I disease. Levels of serum HE<sub>4</sub>
 greater than 140PM and CA<sub>125</sub>
 greater than 35 ku/L were observed in 12 (17%) and 26 (38.2%) of patients respectively whose greater proportion were cases with deep myometrial invasion and high grade tumor. In the evaluation of deep tumoral invasion (> 50%) of the myometrium sensitivity, specificity, and diagnostic accuracy of MRI were 68.9%, 94.8% and 83.8% respectively. For lymph node involvement these values were 50%, 95.1% and 91.1% respectively and for cervical stromal involvement were 64.3%, 98.1% and 91.1% respectively.</p>
<p><bold>Conclusion:</bold>
 Higher stage, deep myometrial invasion, and lymph node or cervical stromal involvement increase diagnostic accuracy of MRI. Higher levels of HE<sub>4</sub>
 and CA<sub>125</sub>
 were observed in patients with deep myometrial invasion and higher grade of tumor.</p>
</div>
</front>
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Utility of Pelvic MRI and Tumor Markers HE4 and CA125 to Predict Depth of Myometrial Invasion and Cervical Involvement in Endometrial Cancer

Utility of Pelvic MRI and Tumor Markers HE4 and CA125 to Predict Depth of Myometrial Invasion and Cervical Involvement in Endometrial Cancer

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